DDD для комбинированных препаратов

DDDs FOR COMBINED PRODUCTS

January 2007



The DDDs assigned for combination products are based on the main principle of counting the combination as one daily dose, regardless of the number of active ingredients included in the combination. If a treatment schedule for a patient includes e.g. two single ingredient products, then the consumption will be measured by counting the DDDs of each single ingredient product separately. If , however, a treatment schedule includes a combination product containing two active ingredients, then the calculated consumption measured in DDDs will normally be lower since the DDD for the combination will be counted.
Principles for assigning DDDs to combination products are described in the Guidelines for ATC classification and DDD assignment or see website (the ATC/DDD system):

For combination products or products where a DDD for various reasons cannot be given in amount of active ingredient, the unit UD (unit dose) is used:


- Tablets, suppositories, pessaries, etc:
1 UD equals 1 tablet, 1 suppository, 1 pessary etc.

- Powder for oral use:
1 UD equals 1 gram of powder.

- Powder in single dose units for oral use:
1 UD equals 1 unit dose powder.

- Powder for injection:
1 UD equals 1 gram of powder.

- Powder for inhalation:
1 UD equals 1 unit dose powder, e.g. 1 capsule.

- Liquid preparations for oral use (mixtures, syrups etc.):
1 UD equals 5 ml of the preparation.

- Liquid preparations for parenteral use (injections):
1 UD equals 1 ml of the preparation.

- Liquid preparations for rectal use:
1 UD equals 1 ml of the preparation.

- Liquid preparations for inhalation:
1 UD equals 1 ml of the preparation.

- Liquid preparations for inhalation in single dose units (unit dose):
1 UD equals 1 unit dose inhal.sol

- Enemas:
1 UD equals 1 enema.

- Plaster for transdermal application:
1 UD equals 1 plaster.

- Vaginal cream:
1 UD equals 1 dose, 1 application.

ATC Code Brand name Dosage form Active ingredients per unit dose (UD) DDD comb.
 A03AX58 * Meteospasmyl  Caps  Alverine 60 mg/simethicone 0.3 g  2 UD (=2 caps)
 A06AB58  Pico-salax  Powder, single dose sachets  Sodium picosulfate 5 mg/Magnesium oxide 3.5 g  2 UD (=2 sachets)
 A06AD61  Milaxulose Oral paste  0.35 g lactulose/ 0.64 g liquid and soft paraffin  2 UD (=10 ml)
 A06AD65  Movicol  Powder, single dose sachets  Polyetylenglycol 13.125 g/Sodiumbicarbonate 178.5 mg  2 UD (=2 sachets)
 A07DA53  Imodium plus  Chew.tab  Loperamide 2 mg/Simeticone 0.125 g  4 UD (=4 tab)
 A09AA02  Combizym  Tab  Multienzymes (lipase, protease etc.)  4 UD (=4 tab)
 A09AA02  Creon  Enterocaps  Multienzymes (lipase, protease etc.)  6 UD (=6 caps)
 A09AA02  Creon forte  Enterocaps  Multienzymes (lipase, protease etc.)  4 UD (=4 tab)
 A09AA02  Pancrease  Enterocaps  Multienzymes (lipase, protease etc.)  6 UD (=6 tab)
 A10BD02  Glucovance  Tab  Metformin 0.5 g/Glibenclamide 2.5 mg  2 UD (=2 tab)
 A10BD02  Glucovance  Tab  Metformin 0.5 g/Glibenclamide 5 mg  2 UD (=2 tab)
 A10BD03  Avandamet  Tab  Metformin 0.5 g/Rosiglitazone 1 mg  2 UD (=2 tab)
 A10BD03  Avandamet  Tab  Metformin 0.5 g/Rosiglitazone 2 mg  2 UD (=2 tab)
 A10BD03  Avandamet  Tab  Metformin 0.5 g/Rosiglitazone 4 mg  2 UD (=2 tab)
 A10BD03  Avandamet  Tab  Metformin 1 g/Rosiglitazone 2 mg  2 UD (=2 tab)
 A10BD03  Avandamet  Tab  Metformin 1 g/Rosiglitazone 4 mg  2 UD (=2 tab)
 A10BD04  Avandaryl  Tab  Glimepiride 1 mg/Rosiglitazone 4 mg  1 UD (=1 tab)
 A10BD04  Avandaryl  Tab  Glimepiride 2 mg/Rosiglitazone 4 mg  1 UD (=1 tab)
 A10BD04  Avandaryl  Tab  Glimepiride 4 mg/Rosiglitazone 4 mg  1 UD (=1 tab)
 A10BD04  Avandaryl  Tab  Glimepiride 1 mg/Rosiglitazone 8 mg  1 UD (=1 tab)
 A10BD04  Avandaryl  Tab  Glimepiride 2 mg/Rosiglitazone 8 mg  1 UD (=1 tab)
 A10BD04  Avandaryl  Tab  Glimepiride 4 mg/Rosiglitazone 8mg  1 UD (=1 tab)
 A10BD05  Actoplus met  Tab  Metformin 500 mg/Pioglitazone 15 mg  2 UD (=2 tab)
 A10BD05  Actoplus met  Tab  Metformin 850 mg/Pioglitazone 15 mg  2 UD (=2 tab)
 A10BD05  Competact  Tab  Metformin 850 mg/Pioglitazone 15 mg  2 UD (=2 tab)
 B01AC30  Asasantin Retard  Caps  Dipyridamole 0.2 g/Acetylsalicylic acid 25 mg  2 UD (=2 tab)
 C10BA02  Inegy  Tab  Simvastatin 20 mg/ Ezetimibe 10 mg  1 UD (=1 tab)
 C10BA02  Inegy  Tab  Simvastatin 40 mg/ Ezetimibe 10 mg  1 UD (=1 tab)
 C10BA02  Inegy  Tab  Simvastatin 80 mg/ Ezetimibe 10 mg  1 UD (=1 tab)
 G03HB01  Diane  Tab  Cyproterone 2 mg/Ethinylestradiol 35 mcg  0.75 UD (=0.75 tab)
 G04BE30  Androskat  Inj  Papaverine 15 mg/Phentolamine 0.5 mg  1 UD (= 1 ml)
 J01AA20  Deteclo  Tab  Tetracycline 115.4 mg/Chlortetracycline 115.4 mg/Demeclocycline 69.2 mg  2 UD (=2 tab)
 J01CA20  Miraxid  Tab  Pivampicillin 0.25 g/Pivmecillinam 0.2 g  3 UD (=3 tab)
 J01CA20  Miraxid mite  Tab  Pivampicillin 0.125 g/Pivmecillinam 0.1 g  6 UD (=6 tab)
 J01CE30  Bicillin C-R, Bicillin A-P, Bicillin  Powder for inj  Comb. of Benzylpenicillin/Procain-benzylpenicillin/Benzathine benzylpenicillin  3.6 g expressed as benzylpenicillin
 J01CR50  Ampiclox  Tab  Ampicillin 0.25 g/Cloxacillin 0.25 g  4 UD (=4 tab)
 J01CR50  Ampoxium  Powder for inj  Ampicillin 0.66 g/Oxacillin 0.33 g  2 UD (= 2 g)
 J01CR50  Ampoxium  Caps  Ampicillin 0.125g/Oxacillin 0.125 g  8 UD (= 8 caps)
 J01CR50  Co-fluampicil  Tab  Ampicillin 0.25 g/Flucloxacillin 0.25 g  4 UD (=4 tab)
 J01EC20  Trisulfamid  Tab  Sulfacarbamide 0.167 g/Sulfadiazine 0.167 g/Sulfadimidine 0.167 g
 4 UD (=4 tab)
 J01EE01  Bactrim, Eusaprim, Trimetoprim-sulfa  Inf.conc  Sulfamethoxazole 80 mg/ Trimethoprim 16 mg  20 UD (=20 ml)
 J01EE01  Bactrim, Eusaprim, Trimetoprim-sulfa  Mixt  Sulfamethoxazole 0.2 g/ Trimethoprim 40 mg  8 UD (= 40 ml)
 J01EE01  Bactrim, Eusaprim, Trimetoprim-sulfa  Tab  Sulfamethoxazole 0.4 g / Trimethoprim 80 mg  4 UD (=4 tab)
 J01EE02  Triglobe, Trimin Sulfa  Mixt  Sulfadiazine 0.205 g/ Trimethoprim 45 mg  4 UD (=20 ml)
 J01EE02  Triglobe, Trimin Sulfa  Tab  Sulfadiazine 0.41 g/ Trimethoprim 90 mg  2 UD (=2 tab)
 J01EE03  Lidaprim  Tab  Sulfametrole 0.8 g/ Trimethoprim 0.16 g  2 UD (=2 tab)
 J01EE03  Lidaprim  Powder for inj  Sulfametrole 0.8 g/ Trimethoprim 0.16 g per vial  2 UD (defined as 2 vials)
 J01EE06  Sterinor  Tab  Sulfadiazin 0.25 g/ Tetroxoprim 0.1 g  2 UD (=2 tab)
 J01EE07  Berlocombin  Tab  Sulfamerazin 0.12 g/ Trimethoprim 80 mg  4 UD (=4 tab)
 J04AM02  Rifinah  Tab  Rifampicin 0.3 g/ Isoniazid 0.15 g  2 UD (=2 tab)
 J04AM02  Rifinah  Tab  Rifampicin 0.15 g/ Isoniazid 0.1 g  4 UD (=4 tab)
 J04AM02  Rimactazid  Tab  Rifampicin 0.15 g/ Isoniazid 75 mg  4 UD (=4 tab)
 J04AM05  Rifater  Tab  Rifampicin 0.12 g/ Isoniazid 50 mg/
Pyrazinamide 0.3 g
 6 UD (=6 tab)
 J04AM05  Rimcure  Tab  Rifampicin 0.15 g/ Isoniazid 75 mg/
Pyrazinamide 0.4 g
 4 UD (=4 tab)
 J04AM06  Rimstar  Tab  Rifampicin 0.15 g/ Ethambutol 0.275 g / Isoniazid 75 mg/ Pyrazinamide 0.4 g  4 UD (=4 tab)
 J05AR01  Combivir  Tab  Lamivudine 0.15 g/ Zidovudine 0.3 g  2 UD (=2 tab)
 J05AR02  Kivexa  Tab  Abacavir 0.6 g/ Lamivudine 0.3 g  1 UD (=1 tab)
 J05AR03  Truvada  Tab  Emtricitabine 0.2 g/ Tenofovir disoproxil 0.245 g  1 UD (=1 tab)
 J05AR04  Trizivir  Tab  Zidovudine 0.3 g/ Lamivudine 0.15 g/
Abacavir 0.3 g
 2 UD (=2 tab)
 M03BA52  Somadril comp  Tab  Carisoprodol 0.2 g/ Paracetamol 0.16 g/Caffeine 32 mg
 4 UD (=4 tab)
 M03BB52  Lobac  Tab  Chlormezanone 0.1 g/ Paracetamol 0.45 g  4 UD (=4 tab)
 M03BB53  Paraflex Comp  Tab  Chorzoxazone 0.125 g/ Acetylsalicylic acid 0.5 g/ Dextropropoxifene (napsylate) 45 mg
 4 UD (=4 tab)
 M03BC51  Norgesic  Tab  Orphenadrine 35 mg/ Paracetamol 0.45 g  4 UD (=4 tab)
 N02AA59  Codeine/ paracetamol  supp  Codeine 20 mg/ Paracetamol 1.0 g  3 UD (=3 supp)
 N02AA59  Paralgin forte  Tab  Codeine 30 mg/ Paracetamol 0.4 g  3 UD (=3 tab)
 N02AA59  Paralgin forte  supp  Codeine 30 mg/ Paracetamol 0.4 g  3 UD (=3 supp)
 N02AA59  Citodon, Parkodin forte, Panocod, Pinex forte  Tab  Codeine 30 mg/ Paracetamol 0.5 g  3 UD (=3 tab)
 N02AA59  Citodon  supp  Codeine 30 mg/ Paracetamol 0.5 g  3 UD (=3 supp)
 N02AA59  Codeine/ paracetamol  supp  Codeine 40 mg/ Paracetamol 0.5 g  3 UD (=3 supp)
 N02AA59  Codeine/ paracetamol  Tab  Codeine 50 mg/ Paracetamol 0.5 g  3 UD (=3 tab)
 N02AA59  Citodon forte  supp  Codeine 60 mg/ Paracetamol 1 g  1.5 UD (=1.5 supp)
 N02AC54  Aporex  Tab  Dextropropoxyphene 70 mg/ Paracetamol 0.4 g  2 UD (=2 tab)
 N02AG01  Morfin-skopolamin  Inj  Morphine 10 mg/ Scopolamine 0.4 mg  1 UD (=1 ml)
 N02AG02  Ketogan  supp  Ketobemidone 10 mg/ Dimethylaminodiphenylbutene 50 mg  2.5 UD (=2.5 supp)
 N02AX52  Ultracet/Zaldiar  Tab  Tramadol 37.5 mg/ Paracetamol 0.325 g  4 UD (=4 tab)
 N02BA51  Migrafin  Powder, single dose sachets  Acetylsalicylic acid 0.9 g/ Metoclopramide 10 mg  3 UD (=3 sachets)
 N06CA02  Deanxit  Tab  Melitracen 10 mg/ Flupentixol 0.5 mg  1 UD (=1 tab)
 N07AA51  Robinul-Neostigmine  Inj  Glycopyrronium 0.5 mg/ Neostigmine 2.5 mg  1 UD (=1ml)
 P01BB51  Malarone  Tab  Atovaquone 0.25 g/ Proguanil hydrochloride 0.1 g  4 UD (=4 tab)
 P01BB51  Malarone junior  Tab  Atovaquone 62.5 mg/ Proguanil hydrochloride 25 mg
 16 UD (=16 tab)
 R03AK03  Berodual  Inhal.aer  Fenoterol 50 mcg/ Ipratropium bromide 20 mcg  6 UD (=6 doses inhal.aer)
 R03AK04  Combivent  Inhal.aer  Salbutamol 0.12 mg/ Ipratropium bromide 20 mcg  6 UD (=6 doses inhal.aer)
 R03AK04  Combivent Unit Dose  Inhal.sol  Salbutamol 2.5 mg/ Ipratropium bromide 0.5 mg/ vial:2.5 ml  3 UD (=3 vials inhal.sol)
 R03AK06  Seretide  Inhal.powd  Salmeterol 50 mcg/ Fluticasone 0.1 mg (metered dose)  2 UD (=2 inhal.powd)
 R03AK06  Seretide  Inhal.powd  Salmeterol 50 mcg/ Fluticasone 0.25 mg (metered dose)  2 UD (=2 inhal.powd)
 R03AK06  Seretide  Inhal.powd  Salmeterol 50 mcg/ Fluticasone 0.5 mg (metered dose)  2 UD (=2 inhal.powd)
 R03AK06  Seretide  Inhal.aer  Salmeterol 25 mcg/ Fluticasone 50 mcg (metered dose)  4 UD (=4 doses inhal.aer)
 R03AK06  Seretide  Inhal.aer  Salmeterol 25 mcg/ Fluticasone 0.125 mg (metered dose)  4 UD (=4 doses inhal.aer)
 R03AK06  Seretide  Inhal.aer  Salmeterol 25 mcg/ Fluticasone 0.25 mg (metered dose)  4 UD (=4 doses inhal.aer)
 R03AK07  Symbicort mite  Inhal.powd Turbohaler  Formoterol 4.5 mcg / Budesonide 80 mcg (delivered dose)  4 UD (=4 inhal.powd)
 R03AK07  Symbicort  Inhal.powd Turbohaler  Formoterol 4.5 mcg / Budesonide 0.16 mg (delivered dose)  4 UD (=4 inhal.powd)
 R03AK07  Symbicort forte  Inhal.powd Turbohaler  Formoterol 9 mcg/ Budesonide 0.32 mg (delivered dose)  2 UD (=2 inhal.powd)

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